Fig. 6. Antitumor effect of SF1126 against HT-29 xenograft in nude mice. Five million HT-29 cells were injected subcutaneously in each nude mouse. After 20 days, HT-29 tumor-bearing mice were randomly divided in to three groups (n = 10 per group), treated daily with SF1126 (20 or 50-mg/kg body weight, subcutaneous) or saline vehicle control ("Vehicle"). Tumor volume (A) and mice body weight (D) were recorded every 6 days. The estimated daily tumor growth (in mm³ per day, B) and tumor weights at Day36 (C) are shown.*p< 0.05 vs. the "Vehicle" group (A-C). ^# p< 0.05 vs. the 20 mg/kg SF1126 group(A-C).